Differential Effects of the Type I Interferons
نویسندگان
چکیده
منابع مشابه
The Jak-Stat Signaling Pathway of Interferons System: Snapshots
Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...
متن کاملSignal transduction by type I interferons.
The two classes of interferons, type I (IFNalpha, IFNbeta, IFNomega, and IFNtau) and type II (IFNgamma) are pleiotropic cytokines that exhibit antiviral, antiproliferative, and immunomodulatory effects on their target cells. This article summarizes the advances made in elucidating the molecular events that mediate the biological responses to type I interferons.
متن کاملHuman Immunodeficiency Virus 1 and Type I Interferons—Where Sex Makes a Difference
The human immunodeficiency virus (HIV)-1 epidemic continues to represent a global health problem that is over-proportionally affecting women from sub-Saharan Africa. Besides social and environmental factors, the modulation of immunological pathways by sex hormones and gene dosage effects of X chromosomal-encoded genes have been suggested to lead to differential outcomes in HIV-1 disease. Women ...
متن کاملINVENTORY MODEL WITH DEMAND AS TYPE-2 FUZZY NUMBER: A FUZZY DIFFERENTIAL EQUATION APPROACH
An inventory model is formulated with type-2 fuzzy parameters under trade credit policy and solved by using Generalized Hukuhara derivative approach. Representing demand parameter of each expert's opinion is a membership function of type-1 and thus, this membership function again becomes fuzzy. The final opinion of all experts is expressed by a type-2 fuzzy variable. For this present problem, t...
متن کاملاینترفرون ها در بیماری‌های خود ایمن: دوست یا دشمن
Interferons (IFNs) are pleotropic cytokines with strong anti-viral and immunomodulatory properties. Their function is dependent to signaling pathway upon binding to IFN receptor. Both pro- and anti-inflammatory effects are seen in interferons-related immune responses. While, interferons are in direct correlation with autoantibodies production during autoimmunity, they have protective effects. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008